Flint Lockwood now works at The Live Corp Company for his idol Chester V. But he's forced to leave his post when he learns that his most infamous machine is still operational, and is churning out menacing food-animal hybrids.
A young and parentless girl adopts a 'dog' from the local pound, completely unaware that it's supposedly a dangerous scientific experiment that's taken refuge on Earth and is now hiding from its creator and those who see it as a menace.